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Literature summary extracted from

  • Ohshima, N.; Kudo, T.; Yamashita, Y.; Mariggio, S.; Araki, M.; Honda, A.; Nagano, T.; Isaji, C.; Kato, N.; Corda, D.; Izumi, T.; Yanaka, N.
    New members of the mammalian glycerophosphodiester phosphodiesterase family GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity (2015), J. Biol. Chem., 290, 4260-4271 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 expression in Sf9 cell Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.39 0.32
-
 1-O-alkyl-sn-glycero-3-phosphocholine pH 7.4, temperature not specified in the publication Mus musculus
3.1.4.39 1
-
 lysophosphatidylcholine pH 7.4, temperature not specified in the publication Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus Q9CRY7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 brain
-
 Mus musculus
-
3.1.4.39 colon
-
 Mus musculus
-
3.1.4.39 intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 1-O-alkyl-sn-glycero-3-phosphocholine + H2O i.e. lyso-platelet-activating factor Mus musculus 1-O-alkyl-sn-glycerol 3-phosphate + choline
-
 ?
3.1.4.39 lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.39 ? x * 37000, SDS-PAGE Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.4.39 0.032
-
 lysophosphatidylcholine pH 7.4, temperature not specified in the publication Mus musculus
3.1.4.39 0.077
-
 1-O-alkyl-sn-glycero-3-phosphocholine pH 7.4, temperature not specified in the publication Mus musculus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.1.4.39 0.031
-
 lysophosphatidylcholine pH 7.4, temperature not specified in the publication Mus musculus
3.1.4.39 0.24
-
 1-O-alkyl-sn-glycero-3-phosphocholine pH 7.4, temperature not specified in the publication Mus musculus