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Literature summary extracted from
- Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase (2004), J. Am. Chem. Soc., 126, 16742-16743 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.15.37 | expression in Streptomyces lividans | Streptomyces thioluteus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.37 | Streptomyces thioluteus | Q70KH6 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.37 | luteothin + 2 O2 + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ | luteothin i.e. deoxyaureothin | Streptomyces thioluteus | aureothin + 3 H2O + 4 oxidized ferredoxin [iron-sulfur] cluster | - |
? |  |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.15.37 | physiological function | knockout of AurH in the aureothin biosynthesis gene cluster leads to accumulation of luteothin. AurH catalyzes the formation of the homochiral furan ring of aureothin, which constitutes the last step in the biosynthetic pathway | Streptomyces thioluteus |
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Release 2023.1 (January 2023)
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