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Literature summary extracted from

  • Wang, H.; Nair, V.S.; Holland, A.A.; Capolicchio, S.; Jessen, H.J.; Johnson, M.K.; Shears, S.B.
    Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity (2015), Biochemistry, 54, 6462-6474 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.B18 expression in Drosophila melanogaster Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.B18 additional information a recombinant Asp1 construct that contains the putative phosphatase domain residues Asp1371-920, is able to dephosphorylate substrates 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate and 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate Schizosaccharomyces pombe

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.B18 Homo sapiens Q6PFW1 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-
3.6.1.B18 Schizosaccharomyces pombe O74429 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-
3.6.1.B18 Schizosaccharomyces pombe 972 O74429 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate (2) Schizosaccharomyces pombe
a
3.6.1.B18 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate (1) Schizosaccharomyces pombe
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O
-
 Schizosaccharomyces pombe 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate
-
 ?
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O
-
 Schizosaccharomyces pombe 972 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate
-
 ?
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O
-
 Homo sapiens 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate
-
 ?
3.6.1.B18 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O
-
 Schizosaccharomyces pombe 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
-
 ?
3.6.1.B18 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O
-
 Schizosaccharomyces pombe 972 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
-
 ?
3.6.1.B18 additional information enzyme specifically hydrolyzes the 1-diester phosphate of 1-InsP7 and 1,5-InsP8. No substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Schizosaccharomyces pombe ?
-
 ?
3.6.1.B18 additional information no substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Homo sapiens ?
-
 ?
3.6.1.B18 additional information enzyme specifically hydrolyzes the 1-diester phosphate of 1-InsP7 and 1,5-InsP8. No substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Schizosaccharomyces pombe 972 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.B18 ASP1
-
 Homo sapiens
3.6.1.B18 ASP1
-
 Schizosaccharomyces pombe

Cofactor

EC Number Cofactor Comment Organism Structure
3.6.1.B18 2Fe-2S-center presence of about 2 atoms of iron and acid-labile sulfide per Asp1 molecule. The [2Fe-2S]2+ cluster substantially inhibits the phosphatase activity of Asp1 Schizosaccharomyces pombe