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Literature summary extracted from

  • Li, J.; Lee, E.J.; Chang, L.; Facchini, P.J.
    Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae (2016), Sci. Rep., 6, 39256 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.78 expression in Escherichia coli and in Saccharomyces cereviseae Thalictrum flavum
4.2.1.78 expression in Escherichia coli and in Saccharomyces cereviseae Papaver somniferum
4.2.1.78 expression in Escherichia coli and in Saccharomyces cereviseae Nandina domestica
4.2.1.78 expression in Escherichia coli and in Saccharomyces cereviseae Corydalis chinensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.78 0.347
-
 dopamine pH 7.3, 37°C Nandina domestica
4.2.1.78 0.48
-
 4-hydroxyphenylacetaldehyde pH 7.3, 37°C Nandina domestica
4.2.1.78 0.502
-
 dopamine pH 7.3, 37°C Corydalis chinensis
4.2.1.78 1.829
-
 4-hydroxyphenylacetaldehyde pH 7.3, 37°C Corydalis chinensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Thalictrum flavum the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Papaver somniferum the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Nandina domestica the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Corydalis chinensis the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis (S)-norcoclaurine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.78 Corydalis chinensis
-
-
-
4.2.1.78 Nandina domestica
-
-
-
4.2.1.78 Papaver somniferum Q4QTJ1
-
-
4.2.1.78 Papaver somniferum Q4QTJ2
-
-
4.2.1.78 Thalictrum flavum Q67A25
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Thalictrum flavum (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Papaver somniferum (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Nandina domestica (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Corydalis chinensis (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Thalictrum flavum (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Papaver somniferum (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Nandina domestica (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Corydalis chinensis (S)-norcoclaurine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.78 CCHNCS2
-
 Corydalis chinensis
4.2.1.78 NDONCS3
-
 Nandina domestica
4.2.1.78 PSONCS1
-
 Papaver somniferum
4.2.1.78 PSONCS2
-
 Papaver somniferum
4.2.1.78 TFLNCSDELTA25
-
 Thalictrum flavum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.78 1.7
-
 4-hydroxyphenylacetaldehyde pH 7.3, 37°C Nandina domestica
4.2.1.78 2.4
-
 dopamine pH 7.3, 37°C Nandina domestica
4.2.1.78 5.3
-
 4-hydroxyphenylacetaldehyde pH 7.3, 37°C Corydalis chinensis
4.2.1.78 5.8
-
 dopamine pH 7.3, 37°C Corydalis chinensis

General Information

EC Number General Information Comment Organism
4.2.1.78 metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Thalictrum flavum
4.2.1.78 metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Papaver somniferum
4.2.1.78 metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Nandina domestica
4.2.1.78 metabolism the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis Corydalis chinensis