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Literature summary extracted from

  • Crowther, G.; Booker, M.; He, M.; Li, T.; Raverdy, S.; Novelli, J.; He, P.; Dale, N.; Fife, A.; Barker Jr., R.; Kramer, M.; Van Voorhis, W.; Carlow, C.; Wang, M.
    Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens (2014), PLoS Negl. Trop. Dis., 8, e2628 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.12 1,10-phenanthrolin-5-amine
-
 Brugia malayi
5.4.2.12 1,10-phenanthrolin-5-amine
-
 Caenorhabditis elegans
5.4.2.12 2-cyclohexyl-5-ethylthieno[3,2-d][1,2]thiazol-2-ium
-
 Brugia malayi
5.4.2.12 2-cyclohexyl-5-ethylthieno[3,2-d][1,2]thiazol-2-ium
-
 Caenorhabditis elegans
5.4.2.12 Genzyme-2
-
 Brugia malayi
5.4.2.12 Genzyme-2
-
 Caenorhabditis elegans
5.4.2.12 NCDS-1
-
 Brugia malayi
5.4.2.12 NCDS-1
-
 Caenorhabditis elegans
5.4.2.12 Tannic acid
-
 Brugia malayi
5.4.2.12 Tannic acid
-
 Caenorhabditis elegans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.2.12 0.37
-
 3-phospho-D-glycerate at pH 7.9 and 20°C Brugia malayi
5.4.2.12 0.38
-
 3-phospho-D-glycerate at pH 7.9 and 20°C Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.2.12 2-phospho-D-glycerate Caenorhabditis elegans
-
 3-phospho-D-glycerate
-
 r
5.4.2.12 2-phospho-D-glycerate Brugia malayi
-
 3-phospho-D-glycerate
-
 r
5.4.2.12 3-phospho-D-glycerate Caenorhabditis elegans
-
 2-phospho-D-glycerate
-
 r
5.4.2.12 3-phospho-D-glycerate Brugia malayi
-
 2-phospho-D-glycerate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.12 Brugia malayi Q4VWF8
-
-
5.4.2.12 Caenorhabditis elegans G5EFZ1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.12 2-phospho-D-glycerate
-
 Caenorhabditis elegans 3-phospho-D-glycerate
-
 r
5.4.2.12 2-phospho-D-glycerate
-
 Brugia malayi 3-phospho-D-glycerate
-
 r
5.4.2.12 3-phospho-D-glycerate
-
 Caenorhabditis elegans 2-phospho-D-glycerate
-
 r
5.4.2.12 3-phospho-D-glycerate
-
 Brugia malayi 2-phospho-D-glycerate
-
 r

Subunits

EC Number Subunits Comment Organism
5.4.2.12 ? x * 57000, SDS-PAGE Brugia malayi
5.4.2.12 ? x * 59000, SDS-PAGE Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
5.4.2.12 cofactor-independent phosphoglycerate mutase
-
 Caenorhabditis elegans
5.4.2.12 cofactor-independent phosphoglycerate mutase
-
 Brugia malayi
5.4.2.12 iPGAM
-
 Caenorhabditis elegans
5.4.2.12 iPGAM
-
 Brugia malayi

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.2.12 additional information the enzyme is independent from 2,3-bisphosphoglycerate Caenorhabditis elegans
5.4.2.12 additional information the enzyme is independent from 2,3-bisphosphoglycerate Brugia malayi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.2.12 0.0067
-
 pH and temperature not specified in the publication Caenorhabditis elegans 2-cyclohexyl-5-ethylthieno[3,2-d][1,2]thiazol-2-ium
5.4.2.12 0.0104
-
 pH and temperature not specified in the publication Brugia malayi 2-cyclohexyl-5-ethylthieno[3,2-d][1,2]thiazol-2-ium
5.4.2.12 0.0383
-
 pH and temperature not specified in the publication Brugia malayi 1,10-phenanthrolin-5-amine