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Literature summary extracted from

  • Salim, V.; Wiens, B.; Masada-Atsumi, S.; Yu, F.; De Luca, V.
    7-deoxyloganetic acid synthase catalyzes a key 3 step oxidation to form 7-deoxyloganetic acid in Catharanthus roseus iridoid biosynthesis (2014), Phytochemistry, 101, 23-31 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.161 expression of the gene in Saccharomyces cerevisiae confirms its function as an authentic 7-deoxyloganetic acid synthase that catalyzes the 3 step oxidation of iridodial-nepetalactol to form 7-deoxyloganetic acid Catharanthus roseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.161 (+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 Catharanthus roseus the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.161 (+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 Catharanthus roseus cv. Little Delicata the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.161 Catharanthus roseus W8JIS5
-
-
1.14.14.161 Catharanthus roseus cv. Little Delicata W8JIS5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.161 (+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction Catharanthus roseus 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.161 (+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction Catharanthus roseus cv. Little Delicata 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
 ?
1.14.14.161 (+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.161 (+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus cv. Little Delicata 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.161 7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.14.161 7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus cv. Little Delicata iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.14.161 iridotrial + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.161 iridotrial + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus cv. Little Delicata 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.161 7-deoxyloganetic acid synthase
-
 Catharanthus roseus
1.14.14.161 7DLS
-
 Catharanthus roseus
1.14.14.161 CYP76A26
-
 Catharanthus roseus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.161 cytochrome P-450 a cytochrome P-450 (heme thiolate) enzyme Catharanthus roseus

General Information

EC Number General Information Comment Organism
1.14.14.161 malfunction virus-induced gene silencing of 7-deoxyloganetic acid synthase in Catharanthus roseus greatly decreases levels of secologanin and the major monoterpenoid indole alkaloids, catharanthine and vindoline in silenced leaves Catharanthus roseus
1.14.14.161 metabolism the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus