EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.4.99.17 | D376C | inactive | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
5.4.99.17 | F365C | the mutant is able to convert geraniol into (S)-gamma-cyclogeraniol and cyclogeraniol hydrate | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
5.4.99.17 | G600F | the mutant is able to convert geraniol into (S)-gamma-cyclogeraniol and cyclogeraniol hydrate | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
5.4.99.17 | I261A | the mutant exclusively converts (S)-citronellal to ( -)-iso-isopulegol isomer (1R,2S,5S)-5-methyl-2-(prop-1-en-2-yl)cyclohexan-1-ol with an 11times improved activity as compared to the wild type enzyme | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
5.4.99.17 | L607F | the mutant produces the farnesyl ether with 6times higher yield from farnesol than the wild type enzyme | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
5.4.99.17 | Y420W/G600F | the mutant produces selectively (1S)-3-(hydroxymethyl)-2,2-dimethyl-4-methylidenecyclohexan-1-ol from 6,7-epoxygeraniol with a conversion of up to 78% | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.17 | squalene | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | - |
hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene + H2O | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | - |
hopan-22-ol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.4.99.17 | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | P33247 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.4.99.17 | (2E,6E)-farnesol + H2O | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | [(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methanol + [(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methanol + (1S,2R,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol + (1S,2R,4aS,8aS)-1-(hydroxymethyl)-2-O-((2E,6E)-farnesyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol | - |
? | |
5.4.99.17 | 6,7-epoxygeraniol | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | ? | - |
? | |
5.4.99.17 | beta-pinene + H2O | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | alpha-pinene + terpinolene + 1-methyl-4-(propan-2-yl)cyclohexa-1,3-diene + camphene + 2-(4-methylcyclohexa-1,3-dien-1-yl)propan-2-ol + limonene | - |
? | |
5.4.99.17 | citronellal + H2O | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | isopulegol + neo-isopulegol + iso-isopulegol | - |
? | |
5.4.99.17 | additional information | no activity with geraniol | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | ? | - |
? | |
5.4.99.17 | squalene | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | hop-22(29)-ene | - |
? | |
5.4.99.17 | squalene + H2O | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | hopan-22-ol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.4.99.17 | SHC | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |
5.4.99.17 | squalene-hopene cyclase | - |
Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 |