Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Subba Rao, G.; Vijayakrishnan, R.; Kumar, M.
    Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis A computer modelling approach (2008), Chem. Biol. Drug Des., 72, 444-449 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 isoniazid
-
 Mycobacterium tuberculosis
1.3.1.9 Trp-Tyr-Trp structure-based computer modelling approach to design a tripeptide inhibitor. Docking studies indicate that the designed peptide has potency 100 times higher than the best known inhibitor. The results suggest that the designed inhibitor is a suitable lead compound for the development of novel anti-TB drugs Mycobacterium tuberculosis
1.3.1.118 isoniazid
-
 Mycobacterium tuberculosis
1.3.1.118 Trp-Tyr-Trp structure-based computer modelling approach to design a tripeptide inhibitor. Docking studies indicate that the designed peptide has potency 100 times higher than the best known inhibitor. The results suggest that the designed inhibitor is a suitable lead compound for the development of novel anti-TB drugs Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Mycobacterium tuberculosis P9WGR1
-
-
1.3.1.9 Mycobacterium tuberculosis ATCC 25618 P9WGR1
-
-
1.3.1.118 Mycobacterium tuberculosis P9WGR1 cf. EC 1.3.1.9
-
1.3.1.118 Mycobacterium tuberculosis ATCC 25618 P9WGR1 cf. EC 1.3.1.9
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 InhA
-
 Mycobacterium tuberculosis
1.3.1.118 InhA
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.3.1.9 metabolism key enzyme in the biosynthesis of mycolic acids Mycobacterium tuberculosis
1.3.1.118 metabolism key enzyme in the biosynthesis of mycolic acids Mycobacterium tuberculosis