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Literature summary extracted from

  • Tamura, N.; Lottspeich, F.; Baumeister, W.; Tamura, T.
    The role of tricorn protease and its aminopeptidase-interacting factors in cellular protein degradation (1998), Cell, 95, 637-648 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.7
-
 Thermoplasma acidophilum

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Thermoplasma acidophilum O93655
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.11.7 0.6
-
 substrate: L-Arg-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 0.7
-
 substrate: L-Tyr-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 0.8
-
 substrate: L-Phe-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 1
-
 substrate: L-Val-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 1.1
-
 substrate: Gly-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 3
-
 substrate: L-Pro-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 15
-
 substrate: L-Ala-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 34.7
-
 substrate: L-Leu-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3.4.11.7 72.4
-
 substrate: L-Glu-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 Gly-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum Gly + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Ala-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Ala + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Arg-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Glu-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Glu + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Leu-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Leu + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Phe-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Phe + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Pro-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Pro + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Tyr-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Tyr + 7-amino-4-methylcoumarin
-
 ?
3.4.11.7 L-Val-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Val + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 tricorn protease-interacting factor F3
-
 Thermoplasma acidophilum

General Information

EC Number General Information Comment Organism
3.4.11.7 metabolism Tricorn, and its interacting factors, F1, F2, and F3 convert proteins efficiently into amino acids. It is quite likely that Tricorn also acts in vivo downstream of the proteasome and, in cooperation with its interacting factors, completes protein catabolic pathways Thermoplasma acidophilum