EC Number | Application | Comment | Organism |
---|---|---|---|
4.3.2.10 | agriculture | development of allosteric antibiotics, herbicides, and antifungal compounds because the enzyme is absent in mammals but provides an entry point to fundamental biosynthetic pathways in plants, fungi, and bacteria | Thermotoga maritima |
4.3.2.10 | pharmacology | development of allosteric antibiotics, herbicides, and antifungal compounds because the enzyme is absent in mammals but provides an entry point to fundamental biosynthetic pathways in plants, fungi, and bacteria | Thermotoga maritima |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.3.2.10 | 7-benzyl-8-[(1-[[(2-hydroxyethyl)amino]methyl]propyl)amino]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-2,6-purinedione | glutaminase activity is substantially suppressed upon binding of the inhibitor to the HisH-HisF interface. The allosteric inhibitor is able to uncouple motions induced by the effector ligand with essential motions in the distant active site, favoring an inactive conformation of this V-type enzyme | Thermotoga maritima |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.3.2.10 | Thermotoga maritima | Q9X0C8 and Q9X0C6 | Q9X0C8: subunit HisH, Q9X0C6: subunit HisF | - |
4.3.2.10 | Thermotoga maritima ATCC 43589 | Q9X0C8 and Q9X0C6 | Q9X0C8: subunit HisH, Q9X0C6: subunit HisF | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.3.2.10 | L-glutamine + H2O | - |
Thermotoga maritima | L-glutamate + NH3 | - |
? | |
4.3.2.10 | L-glutamine + H2O | - |
Thermotoga maritima ATCC 43589 | L-glutamate + NH3 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.3.2.10 | IGPS | - |
Thermotoga maritima |