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Literature summary extracted from

  • Mueller, C.; Binder, U.; Maurer, E.; Grimm, C.; Giera, M.; Bracher, F.
    Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates (2015), Steroids, 101, 1-6 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.41 (3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol selective inhibitors of fungal sterol C22-desaturase. The inhibitor is subjected to antifungal susceptibility testing on patient isolates according to modified EUCAST guidelines. But, the organism shows no significant reduction of cell growth and/or viability up to an inhibitor concentration of 0.1 mg/ml. Thus the sterol C22-desaturase is not an attractive target for the development of antifungals Nakaseomyces glabratus
1.14.19.41 (3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol selective inhibitors of fungal sterol C22-desaturase. The inhibitor is subjected to antifungal susceptibility testing on patient isolates according to modified EUCAST guidelines. But, the organism shows no significant reduction of cell growth and/or viability up to an inhibitor concentration of 0.1 mg/ml. Thus the sterol C22-desaturase is not an attractive target for the development of antifungals Saccharomyces cerevisiae
1.14.19.41 (3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol selective inhibitors of fungal sterol C22-desaturase. The inhibitor is subjected to antifungal susceptibility testing on patient isolates according to modified EUCAST guidelines. But, the organism shows no significant reduction of cell growth and/or viability up to an inhibitor concentration of 0.1 mg/ml. Thus the sterol C22-desaturase is not an attractive target for the development of antifungals Yarrowia lipolytica

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.41 Nakaseomyces glabratus Q56J92
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1.14.19.41 Nakaseomyces glabratus NCCLS 84 Q56J92
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1.14.19.41 Saccharomyces cerevisiae
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1.14.19.41 Saccharomyces cerevisiae ATCC 9763
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1.14.19.41 Yarrowia lipolytica
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1.14.19.41 Yarrowia lipolytica UCDFST 60-26
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General Information

EC Number General Information Comment Organism
1.14.19.41 drug target sterol C22-desaturase is not an attractive target for the development of antifungals Nakaseomyces glabratus