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Literature summary extracted from

  • Pohlentz, G.; Klein, D.; Schwarzmann, G.; Schmitz, D.; Sandhoff, K.
    Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver (1988), Proc. Natl. Acad. Sci. USA, 85, 7044-7048 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.92 Triton X-100
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.92 ganglioside GD3 competitive inhibition of GM2 synthesis Rattus norvegicus
2.4.1.92 ganglioside GM3 competitive inhibition of GD2 synthesis Rattus norvegicus
2.4.1.92 additional information no inhibition by ganglioside GQ1b Rattus norvegicus
2.4.3.8 ganglioside GQ1b
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.92 0.152
-
 ganglioside GD3 pH 7.35, 37°C Rattus norvegicus
2.4.1.92 0.385
-
 ganglioside GM3 pH 7.35, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.92 Golgi vesicle
-
 Rattus norvegicus
-
-
2.4.3.8 Golgi vesicle
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Rattus norvegicus Q10468
-
-
2.4.3.8 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 liver
-
 Rattus norvegicus
-
2.4.3.8 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GD3 ganglioside GD3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->8)-O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide Rattus norvegicus UDP + ganglioside GD2
-
 ?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide Rattus norvegicus UDP + ganglioside GM2
-
 ?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + lactosylceramide
-
 Rattus norvegicus UDP-N-acetyl-alpha-D-galactosamine + ganglioside GA2
-
 ?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramideganglioside Rattus norvegicus CMP + ganglioside GD3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.92 GA2 synthase
-
 Rattus norvegicus
2.4.1.92 GD2 synthase
-
 Rattus norvegicus
2.4.1.92 GM2 synthase
-
 Rattus norvegicus
2.4.3.8 GD3 synthase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.92 37
-
 assay at Rattus norvegicus
2.4.3.8 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.92 7.35
-
 assay at Rattus norvegicus
2.4.3.8 7.35
-
 assay at Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.92 0.066
-
 ganglioside GD3 inhibition of GM2 synthesis, pH 7.35, 37°C Rattus norvegicus
2.4.1.92 0.12
-
 ganglioside GM3 inhibition of GD2 synthesis, pH 7.35, 37°C Rattus norvegicus