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Literature summary extracted from

  • Zhou, Y.; Gong, Z.; Yang, Z.; Yuan, Y.; Zhu, J.; Wang, M.; Yuan, F.; Wu, S.; Wang, Z.; Yi, C.; Xu, T.; Ryom, M.; Gu, M.; Liang, G.
    Mutation of the light-induced yellow leaf 1 gene, which encodes a geranylgeranyl reductase, affects chlorophyll biosynthesis and light sensitivity in rice (2013), PLoS ONE, 8, e75299 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.83 gene LYL1, map-based cloning of LYL1, phylogenetic analysis, quantitative real-time PCR enzyme expression analysis Oryza sativa Japonica Group

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.83 additional information analysis of properties and phenotype of mutant lyl1-1, the mutation of LYL1 leads to an accumulation of Chl intermediates and a deficiency of alpha-tocopherol, overview. The C-to-T substitution results in a change from an alanine residue to valine in the encoded protein in lyl1-1. Enzyme knockout by RNA interference, phenotype of a 3-week-old RNAi transgenic plant Oryza sativa Japonica Group

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.83 geranylgeranyl diphosphate + 3 NADPH + 3 H+ Oryza sativa Japonica Group
-
 phytyl diphosphate + 3 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.83 Oryza sativa Japonica Group U5LY03
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.83 seedling
-
 Oryza sativa Japonica Group
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.83 geranylgeranyl diphosphate + 3 NADPH + 3 H+
-
 Oryza sativa Japonica Group phytyl diphosphate + 3 NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.1.83 ? x * 50000, about, sequence calculation Oryza sativa Japonica Group

Synonyms

EC Number Synonyms Comment Organism
1.3.1.83 geranylgeranyl reductase
-
 Oryza sativa Japonica Group
1.3.1.83 LYL1
-
 Oryza sativa Japonica Group
1.3.1.83 NADPH-dependent geranylgeranyl reductase
-
 Oryza sativa Japonica Group

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.83 FAD the enzyme has a FAD binding domain Oryza sativa Japonica Group
1.3.1.83 NADPH dependent on Oryza sativa Japonica Group

Expression

EC Number Organism Comment Expression
1.3.1.83 Oryza sativa Japonica Group LYL1 is induced by light and suppressed by darkness which is consistent with its potential biological functions down
1.3.1.83 Oryza sativa Japonica Group LYL1 is induced by light and suppressed by darkness which is consistent with its potential biological functions up

General Information

EC Number General Information Comment Organism
1.3.1.83 malfunction the light-induced yellow leaf 1-1 (lyl1-1) mutant is hypersensitive to high-light and defective in the Chl synthesis. The mutation of LYL1 leads to conjugation of the majority of Chl molecules with an unsaturated geranylgeraniol side chain. The lyl1-1 mutant suffers from severe photooxidative damage and displays a drastic reduction in the levels of alpha-tocopherol and photosynthetic proteins. The yellowing of lyl1-1 mutant is caused by high-light stress. Mutant lyl1-1 phenotype, overview Oryza sativa Japonica Group
1.3.1.83 metabolism the three-step hydrogenation of geranylgeranyl diphosphate into phytyl diphosphate, and Chl-geranylgeranylated (ChlGG) and Chl-phytol (ChlPhy) is catalyzed by NADPH-dependent geranylgeranyl reductase. ENzyme LYL1 protects against lipid peroxidation and reactive oxygen species, ROS Oryza sativa Japonica Group
1.3.1.83 physiological function the enzyme is involved in the reduction step from Chl-geranylgeranylated (ChlGG) and geranylgeranyl diphosphate (GGPP) to Chl-phytol (ChlPhy) and phytyl diphosphate (PPP) in rice. Enzyme LYL1 also plays an important role in response to high-light in rice Oryza sativa Japonica Group