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Literature summary extracted from

  • Mattu, S.; Fornari, F.; Quagliata, L.; Perra, A.; Angioni, M.M.; Petrelli, A.; Menegon, S.; Morandi, A.; Chiarugi, P.; Ledda-Columbano, G.M.; Gramantieri, L.; Terracciano, L.; Giordano, S.; Columbano, A.
    The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival (2016), J. Hepatol., 64, 891-898 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.3.15 diagnostics the metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma and it may represent a useful diagnostic and prognostic marker for human hepatocellular carcinoma Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.3.15 gene HAO2, quantitative RT-PCR enzyme expression analysis Rattus norvegicus
1.1.3.15 gene HAO2, quantitative RT-PCR enzyme expression analysis Homo sapiens
1.1.3.15 gene HAO2, quantitative RT-PCR enzyme expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.3.15 additional information Rattus norvegicus hepatocellular carcinoma cells are transduced by a HAO2 encoding lentiviral vector and grafted in mice Rattus norvegicus
1.1.3.15 additional information Rattus norvegicus hepatocellular carcinoma cells are transduced by a HAO2 encoding lentiviral vector and grafted in mice Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.3.15 peroxisome
-
 Rattus norvegicus 5777
-
1.1.3.15 peroxisome
-
 Homo sapiens 5777
-
1.1.3.15 peroxisome
-
 Mus musculus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.15 an (S)-2-hydroxy carboxylate + O2 Rattus norvegicus
-
 a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2 Homo sapiens
-
 a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2 Mus musculus
-
 a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2 Mus musculus C3H
-
 a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2 Rattus norvegicus Fischer 344
-
 a 2-oxo carboxylate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.15 Homo sapiens Q9NYQ3
-
-
1.1.3.15 Mus musculus Q9NYQ2
-
-
1.1.3.15 Mus musculus C3H Q9NYQ2
-
-
1.1.3.15 Rattus norvegicus Q07523
-
-
1.1.3.15 Rattus norvegicus Fischer 344 Q07523
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.15 hepatocellular carcinoma cell HAO2 is downregulated Mus musculus
-
1.1.3.15 hepatocellular carcinoma cell Hao2 is highly significantly downregulated in 12/12 HCCs developed by the CMD protocol and in 16/16 HCCs generated by chronic DENA treatment Rattus norvegicus
-
1.1.3.15 hepatocellular carcinoma cell HAO2 mRNA levels are strongly downregulated in two distinct series of human HCCs, when compared to both normal and cirrhotic peritumoral liver, overview Homo sapiens
-
1.1.3.15 liver
-
 Rattus norvegicus
-
1.1.3.15 liver
-
 Homo sapiens
-
1.1.3.15 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.15 an (S)-2-hydroxy carboxylate + O2
-
 Rattus norvegicus a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2
-
 Homo sapiens a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2
-
 Mus musculus a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2
-
 Mus musculus C3H a 2-oxo carboxylate + H2O2
-
 ?
1.1.3.15 an (S)-2-hydroxy carboxylate + O2
-
 Rattus norvegicus Fischer 344 a 2-oxo carboxylate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.3.15 Hao2
-
 Rattus norvegicus
1.1.3.15 Hao2
-
 Homo sapiens
1.1.3.15 Hao2
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.3.15 FMN dependent on Rattus norvegicus
1.1.3.15 FMN dependent on Homo sapiens
1.1.3.15 FMN dependent on Mus musculus

Expression

EC Number Organism Comment Expression
1.1.3.15 Rattus norvegicus the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents down
1.1.3.15 Homo sapiens the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents down
1.1.3.15 Mus musculus the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents down

General Information

EC Number General Information Comment Organism
1.1.3.15 evolution the enzyme belongs to the family of L-2-hydroxy acid oxidases Rattus norvegicus
1.1.3.15 evolution the enzyme belongs to the family of L-2-hydroxy acid oxidases Homo sapiens
1.1.3.15 evolution the enzyme belongs to the family of L-2-hydroxy acid oxidases Mus musculus
1.1.3.15 physiological function L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis Rattus norvegicus
1.1.3.15 physiological function L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis Homo sapiens
1.1.3.15 physiological function L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis Mus musculus