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Literature summary extracted from

  • Eser, B.; Zhang, X.; Chanani, P.; Begley, T.; Ealick, S.
    From suicide enzyme to catalyst the iron-dependent sulfide transfer in Methanococcus jannaschii thiamin thiazole biosynthesis (2016), J. Am. Chem. Soc., 138, 3639-3642 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.59 expression in Escherichia coli Methanocaldococcus jannaschii

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.59 Ca2+ may substitute for iron Methanocaldococcus jannaschii
2.4.2.59 Co2+ may substitute for iron Methanocaldococcus jannaschii
2.4.2.59 Fe2+ highest levels of activity in presence of FE2+ or Fe3+, iron is involved in sulfur transfer Methanocaldococcus jannaschii
2.4.2.59 Fe3+ highest levels of activity in presence of FE2+ or Fe3+, iron is involved in sulfur transfer Methanocaldococcus jannaschii
2.4.2.59 Mg2+ may substitute for iron Methanocaldococcus jannaschii
2.4.2.59 Mn2+ may substitute for iron Methanocaldococcus jannaschii
2.4.2.59 additional information Cu+ or Cu2+ do not support activity Methanocaldococcus jannaschii
2.4.2.59 Ni2+ may substitute for iron Methanocaldococcus jannaschii
2.4.2.59 Zn2+ may substitute for iron Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.59 Methanocaldococcus jannaschii Q58018
-
-
2.4.2.59 Methanocaldococcus jannaschii DSM 2661 Q58018
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.59 NAD+ + glycine + sulfide
-
 Methanocaldococcus jannaschii nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
-
 ?
2.4.2.59 NAD+ + glycine + sulfide
-
 Methanocaldococcus jannaschii DSM 2661 nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
-
 ?