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Literature summary extracted from
- Estimation of inhibitory effect against tyrosinase activity through homology modeling and molecular docking (2015), Enzyme Res., 2015, 262364 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | arbutin | a glycosylated benzoquinone, ascorbic acid reduces melanin formation via reduction of dopaquinone | Agaricus bisporus |  |
| 1.14.18.1 | arbutin | a glycosylated benzoquinone, ascorbic acid reduces melanin formation via reduction of dopaquinone | Homo sapiens | |
| 1.14.18.1 | ascorbic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | ascorbic acid | - |
Homo sapiens | |
| 1.14.18.1 | kojic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | kojic acid | - |
Homo sapiens | |
| 1.14.18.1 | additional information | automated docking calculations for inhibitor docking to the enzyme structure model, molecular dynamics, overview. Intermolecular interactions and effectiveness of specific inhibition | Agaricus bisporus | |
| 1.14.18.1 | additional information | automated docking calculations for inhibitor docking to the enzyme structure model, molecular dynamics, overview. Intermolecular interactions and effectiveness of specific inhibition. Residues N81, N260, H263, and M280 are involved in the binding of inhibitors to mushroom tyrosinase. E195 and H208 are important residues in bacterial tyrosinase, while E230, S245, N249, H252, V262, and S265 bind to inhibitors and are important in forming Pi interaction in human tyrosinase | Homo sapiens | |
| 1.14.18.1 | tropolone | - |
Agaricus bisporus | |
| 1.14.18.1 | tropolone | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? | |
| 1.14.18.1 | 2 L-dopa + O2 | Homo sapiens | - |
2 dopaquinone + 2 H2O | - |
? | |
| 1.14.18.1 | tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? | |
| 1.14.18.1 | tyrosine + O2 | Homo sapiens | - |
dopaquinone + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
| 1.14.18.1 | Homo sapiens | P14679 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? | |
| 1.14.18.1 | 2 L-dopa + O2 | - |
Homo sapiens | 2 dopaquinone + 2 H2O | - |
? | |
| 1.14.18.1 | tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
| 1.14.18.1 | tyrosine + O2 | - |
Homo sapiens | dopaquinone + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | More | three-dimensional modeling of tyrosinase | Agaricus bisporus |
| 1.14.18.1 | More | three-dimensional modeling of tyrosinase | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | mushroom tyrosinase | - |
Agaricus bisporus |
| 1.14.18.1 | tyr | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 40 | - |
- |
Agaricus bisporus |
| 1.14.18.1 | 50 | - |
- |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 7.4 | - |
assay at | Agaricus bisporus |
| 1.14.18.1 | 7.4 | - |
assay at | Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | metabolism | tyrosinase is a key enzyme in melanogenesis. The catalysis of L-tyrosine to L-dopa is the rate-limiting step of the enzymatic pathway in melanin formation | Agaricus bisporus |
| 1.14.18.1 | metabolism | tyrosinase is a key enzyme in melanogenesis. The catalysis of L-tyrosine to L-dopa is the rate-limiting step of the enzymatic pathway in melanin formation | Homo sapiens |
| 1.14.18.1 | additional information | homology modeling of the enzyme sructure using the crystal structure of bacterial tyrosinase from Bacillus megaterium as template, PDB ID 3NQ1 | Agaricus bisporus |
| 1.14.18.1 | additional information | homology modeling of the enzyme sructure using the crystal structure of bacterial tyrosinase from Bacillus megaterium as template, PDB ID 3NQ1 | Homo sapiens |
| 1.14.18.1 | physiological function | tyrosinase is a key enzyme in melanogenesis, which is essential for pigmentation. The catalysis of L-tyrosine to L-dopa is the rate-limiting step of the enzymatic pathway in melanin formation. Tyrosinase is also an important factor in wound healing and cuticle formation in arthropods and browning in plants | Agaricus bisporus |
| 1.14.18.1 | physiological function | tyrosinase is a key enzyme in melanogenesis, which is essential for pigmentation. The catalysis of L-tyrosine to L-dopa is the rate-limiting step of the enzymatic pathway in melanin formation. Tyrosinase is also an important factor in wound healing and cuticle formation in arthropods and browning in plants | Homo sapiens |
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