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Literature summary extracted from

  • Elovaara, H.; Huusko, T.; Maksimow, M.; Elima, K.; Yegutkin, G.G.; Skurnik, M.; Dobrindt, U.; Siitonen, A.; McPherson, M.J.; Salmi, M.; Jalkanen, S.
    Primary amine oxidase of Escherichia coli is a metabolic enzyme that can use a human leukocyte molecule as a substrate (2015), PLoS ONE, 10, e0142367 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.21 amikacin about 60% residual activity at 1 mM Escherichia coli
1.4.3.21 BTT-2052
-
 Escherichia coli
1.4.3.21 kanamycin about 70% residual activity at 1 mM Escherichia coli
1.4.3.21 additional information not inhibited by gentamycin Escherichia coli
1.4.3.21 Semicarbazide
-
 Escherichia coli
1.4.3.21 sisomycin about 45% residual activity at 1 mM Escherichia coli
1.4.3.21 tobramycin about 40% residual activity at 1 mM Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.21 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.21 isoamylamine + H2O + O2
-
 Escherichia coli isoamylaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 additional information the enzyme can use human granulocytes as a substrate Escherichia coli ?
-
 ?
1.4.3.21 phenylethylamine + H2O + O2
-
 Escherichia coli phenylacetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 propylamine + H2O + O2
-
 Escherichia coli propanal + NH3 + H2O2
-
 ?
1.4.3.21 tryptamine + H2O + O2
-
 Escherichia coli (1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 tyramine + H2O + O2
-
 Escherichia coli 4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.21 CAO
-
 Escherichia coli
1.4.3.21 copper-containing amine oxidase
-
 Escherichia coli
1.4.3.21 PrAO
-
 Escherichia coli
1.4.3.21 tynA
-
 Escherichia coli
1.4.3.21 tyramine oxidase, copper-requiring
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.21 0.00024
-
 at pH 7.4 and 30°C Escherichia coli BTT-2052
1.4.3.21 0.0007
-
 at pH 7.4 and 30°C Escherichia coli Semicarbazide
1.4.3.21 0.8
-
 at pH 7.4 and 30°C Escherichia coli tobramycin
1.4.3.21 1
-
 at pH 7.4 and 30°C Escherichia coli amikacin
1.4.3.21 3.8
-
 at pH 7.4 and 30°C Escherichia coli kanamycin