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Literature summary extracted from

  • Bartosovic, M.; Molares, H.C.; Gregorova, P.; Hrossova, D.; Kudla, G.; Vanacova, S.
    N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3-end processing (2017), Nucleic Acids Res., 45, 11356-11370 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.53 H231A/D233A inactive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.53 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.53 additional information Homo sapiens the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites ?
-
 ?
1.14.11.53 N6-methyladenine in mRNA + 2-oxoglutarate + O2 Homo sapiens
-
 adenine in mRNA + formaldehyde + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.53 Homo sapiens
-
-
-
2.1.1.348 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.53 HEK-293T cell
-
 Homo sapiens
-
2.1.1.348 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.53 additional information the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites Homo sapiens ?
-
 ?
1.14.11.53 N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
 Homo sapiens adenine in mRNA + formaldehyde + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.53 FTO
-
 Homo sapiens
1.14.11.53 m6A mRNA demethylase
-
 Homo sapiens
1.14.11.53 N6-methyladenosine demethylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.53 physiological function the enzyme triggers inclusion of alternatively spliced exons and regulates expression of last exons Homo sapiens
2.1.1.348 physiological function METTL3 knockdown leads to a significant downregulation of 3' terminal exons. Demethylase FTO and METTL3 act reciprocally in the regulation of alternative splicing and 3' untranslated region expression Homo sapiens