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Literature summary extracted from

  • Borisova, M.; Gisin, J.; Mayer, C.
    Blocking peptidoglycan recycling in Pseudomonas aeruginosa attenuates intrinsic resistance to fosfomycin (2014), Microb. Drug Resist., 20, 231-237 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.221 Pseudomonas aeruginosa
-
-
-
2.7.1.221 Pseudomonas aeruginosa PA01
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-
-
2.7.7.99 Pseudomonas putida Q88QT2
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-
2.7.7.99 Pseudomonas putida DSM 6125 Q88QT2
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-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.221 PA0596
-
 Pseudomonas aeruginosa
2.7.7.99 murU
-
 Pseudomonas putida
2.7.7.99 N-acetylmuramate alpha-1-phosphate uridylyltransferase
-
 Pseudomonas putida

General Information

EC Number General Information Comment Organism
2.7.1.221 physiological function MurNAc accumulates in the cell extract of AmgK mutants. Mutant is not impaired in growth in rich medium. Mutant displays a fourfold increase in fosfomycin susceptibility Pseudomonas aeruginosa
2.7.7.99 physiological function the metabolic pathway of anomeric cell wall amino sugar kinase AmgK and uridylyl transferase MurU converts N-acetylmuramic acid to uridine diphosphate-N-acetylmuramic acid. It is responsible for the high intrinsic resistance of Pseudomonas aeruginosa to fosfomycin due to bypassing the fosfomycin-sensitive de novo synthesis of UDP-N-acetylmuramic acid Pseudomonas putida