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Literature summary extracted from

  • Fan, L.; Li, J.; Yu, Z.; Dang, X.; Wang, K.
    The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration (2014), BioMed Res. Int., 2014, 239356 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.29 3,4-dihydroxybenzoate
-
 Homo sapiens
1.14.11.29 ciclopirox olamine
-
 Homo sapiens
1.14.11.29 cobalt chloride
-
 Homo sapiens
1.14.11.29 Cu2+
-
 Homo sapiens
1.14.11.29 deferoxamine
-
 Homo sapiens
1.14.11.29 dimethyloxalylglycine
-
 Homo sapiens
1.14.11.29 FG-2216
-
 Homo sapiens
1.14.11.29 FG-4497
-
 Homo sapiens
1.14.11.29 FG-4592
-
 Homo sapiens
1.14.11.29 FKBP38
-
 Homo sapiens
1.14.11.29 GSK360A
-
 Homo sapiens
1.14.11.29 L-mimosine
-
 Homo sapiens
1.14.11.29 Mn2+
-
 Homo sapiens
1.14.11.29 Morg-1
-
 Homo sapiens
1.14.11.29 TM6008
-
 Homo sapiens
1.14.11.29 TM6089
-
 Homo sapiens
1.14.11.29 Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.29 hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.29 additional information Homo sapiens isozyme PHD2 is more active on hypoxia-inducible factor-1alpha than on hypoxia-inducible factor-2alpha, whereas PHD1 and PHD3 hydroxylate hypoxia-inducible factor-2alpha more efficiently ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.29 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.29 mesenchymal stem cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.29 hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.29 additional information isozyme PHD2 is more active on hypoxia-inducible factor-1alpha than on hypoxia-inducible factor-2alpha, whereas PHD1 and PHD3 hydroxylate hypoxia-inducible factor-2alpha more efficiently Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.29 PHD
-
 Homo sapiens
1.14.11.29 prolyl hydroxylase domain protein
-
 Homo sapiens