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Literature summary extracted from

  • Zhang, D.; Chen, X.; Zhang, R.; Yao, P.; Wu, Q.; Zhu, D.
    Development of beta-amino acid dehydrogenase for the synthesis of beta-amino acids via reductive amination of beta-keto acids (2015), ACS Catal., 5, 2220-2224 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.1.B2 expressed in Escherichia coli BL21(DE3) cells Candidatus Cloacimonas acidaminovorans

Protein Variants

EC Number Protein Variants Comment Organism
1.4.1.B2 E310G the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans
1.4.1.B2 E310G/A314Y the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans
1.4.1.B2 E310S the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans
1.4.1.B2 E310S/A314N the mutant exhibits activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.B2 L-erythro-3,5-diaminohexanoate + H2O + NADP+ Candidatus Cloacimonas acidaminovorans
-
 (S)-5-amino-3-oxohexanoate + NH3 + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.B2 Candidatus Cloacimonas acidaminovorans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.B2 L-erythro-3,5-diaminohexanoate + H2O + NADP+
-
 Candidatus Cloacimonas acidaminovorans (S)-5-amino-3-oxohexanoate + NH3 + NADPH + H+
-
 ?
1.4.1.B2 additional information the enzyme barely shows any activity towards (S)-beta-aminobutyric acid, beta-alanine, (R)-beta-homoserine, (R)-beta-homomethionine, (S)-beta-homoglutamine, (R)-beta-phenylalanine, and (S)-beta-homolysine Candidatus Cloacimonas acidaminovorans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.1.B2 3,5-DAHDH
-
 Candidatus Cloacimonas acidaminovorans

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.B2 NADP+
-
 Candidatus Cloacimonas acidaminovorans