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Literature summary extracted from

  • Liu, C.; Sun, Z.; Shen, S.; Lin, L.; Li, T.; Tian, B.; Hua, Y.
    Identification and characterization of the geranylgeranyl diphosphate synthase in Deinococcus radiodurans (2014), Lett. Appl. Microbiol., 58, 219-224.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.29 gene DR1395, DNA and amino acid sequence determination and analysis, sequence comparison with gene DR0932, recombinant expression in Escherichia coli strain BL21 Deinococcus radiodurans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Deinococcus radiodurans
-
 diphosphate + geranylgeranyl diphosphate
-
 ?
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
-
 diphosphate + geranylgeranyl diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.29 Deinococcus radiodurans Q9RUJ1 gene DR1395
-
2.5.1.29 Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 Q9RUJ1 gene DR1395
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Deinococcus radiodurans diphosphate + geranylgeranyl diphosphate
-
 ?
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539 diphosphate + geranylgeranyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.29 DR1395
-
 Deinococcus radiodurans
2.5.1.29 GGPP synthase
-
 Deinococcus radiodurans
2.5.1.29 GGPPS
-
 Deinococcus radiodurans

General Information

EC Number General Information Comment Organism
2.5.1.29 metabolism the enzyme catalyzes the entrance step in the deinoxanthin biosynthetic pathway Deinococcus radiodurans
2.5.1.29 physiological function the amino acid composition of and around the first aspartate-rich motif of the enzyme is vital for GGPP synthase function. Enzyme DR1395 functions as GGPPS to provide GGPP for the biosynthesis of phytoene and then lycopene Deinococcus radiodurans