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Literature summary extracted from

  • Otzen, C.; Bardl, B.; Jacobsen, I.D.; Nett, M.; Brock, M.
    Candida albicans utilizes a modified beta-oxidation pathway for the degradation of toxic propionyl-CoA (2014), J. Biol. Chem., 289, 8151-8169.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.59 0.13
-
 (S)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
1.1.1.59 0.58
-
 (R)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
1.1.1.59 5.37
-
 3-hydroxypropanoate at pH 9.5 and 22°C Candida albicans
1.1.1.59 46.7
-
 L-serine at pH 9.5 and 22°C Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.59 mitochondrion
-
 Candida albicans 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.59 39200
-
 x * 39200, calculated from amino acid sequence Candida albicans
1.1.1.59 40000
-
 x * 40000, SDS-PAGE Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.59 3-hydroxypropanoate + NAD+ Candida albicans preferred substrate 3-oxopropanoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.59 Candida albicans A0A1D8PQ07
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.59 (R)-3-hydroxyisobutyrate + NAD+
-
 Candida albicans 3-oxoisobutyrate + NADH + H+
-
 ?
1.1.1.59 (S)-3-hydroxyisobutyrate + NAD+
-
 Candida albicans 3-oxoisobutyrate + NADH + H+
-
 ?
1.1.1.59 3-hydroxypropanoate + NAD+ preferred substrate Candida albicans 3-oxopropanoate + NADH + H+
-
 ?
1.1.1.59 L-serine + NAD+
-
 Candida albicans 3-oxo-L-alanine + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.59 ? x * 40000, SDS-PAGE Candida albicans
1.1.1.59 ? x * 39200, calculated from amino acid sequence Candida albicans

Synonyms

EC Number Synonyms Comment Organism
1.1.1.59 Hpd1p
-
 Candida albicans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.59 1.31
-
 (R)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
1.1.1.59 2.48
-
 (S)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
1.1.1.59 9.41
-
 L-serine at pH 9.5 and 22°C Candida albicans
1.1.1.59 30.97
-
 3-hydroxypropanoate at pH 9.5 and 22°C Candida albicans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.59 9.5
-
-
 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.59 NAD+
-
 Candida albicans

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.59 0.202
-
 L-serine at pH 9.5 and 22°C Candida albicans
1.1.1.59 2.26
-
 (R)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
1.1.1.59 5.77
-
 3-hydroxypropanoate at pH 9.5 and 22°C Candida albicans
1.1.1.59 19.1
-
 (S)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans