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Literature summary extracted from

  • Xu, L.; Qian, L.; Kang, J.; Sha, S.; Xin, Y.; Lu, S.; Ma, Y.
    Down-regulation of N-acetylglucosamine-1-phosphate transferase (WecA) enhanced the sensitivity of Mycobacterium smegmatis against rifampin (2016), J. Appl. Microbiol., 121, 966-972.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.35 additional information construction of a Mycobacterium smegmatis wecA knockdown strain by using a tetracycline-inducible expression vector pMind, the expression of WecA is regulated by antisense RNA Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.35 Rifampin the sensitivity of wild-type mc2155 strain against rifampin is enhanced in the presence of low concentrations of tunicamycin, a natural WecA inhibitor. An enzyme knockdown mutant strain also shows increased sensitivity to rifampin Mycolicibacterium smegmatis
2.7.8.35 tunicamycin
-
 Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.35 Mycolicibacterium smegmatis A0R211 gene wecA
-
2.7.8.35 Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 A0R211 gene wecA
-

Synonyms

EC Number Synonyms Comment Organism
2.7.8.35 MSMEG_4947 locus name Mycolicibacterium smegmatis
2.7.8.35 N-acetylglucosamine-1-phosphate transferase
-
 Mycolicibacterium smegmatis
2.7.8.35 WecA
-
 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
2.7.8.35 malfunction a Mycobacterium smegmatis wecA knockdown strain regulated by antisense RNA has a decreased growth rate and the amount of live bacterial cells drops. In addition, the wecA knockdown strain exhibits dramatically morphological alterations. The wecA knockdown strain is more sensitive to rifampin, compared with the wecA normal-expression strain Mycolicibacterium smegmatis
2.7.8.35 physiological function wecA is an essential gene for mycobacterial growth Mycolicibacterium smegmatis