Literature summary extracted from
Palusinska-Szysz, M.; Szuster-Ciesielska, A.; Kania, M.; Janczarek, M.; Chmiel, E.; Danikiewicz, W.
Legionella dumoffii utilizes exogenous choline for phosphatidylcholine synthesis (2014), Int. J. Mol. Sci., 15, 8256-8279.
Application
EC Number |
Application |
Comment |
Organism |
---|
2.7.8.24 |
analysis |
since choline is not a biosynthetic product of prokaryotes, the Pcs pathway is probably a direct sensor of environmental conditions, using choline availability as an indicator of the status of the location in which the bacterium is found |
Fluoribacter dumoffii |
2.7.8.24 |
additional information |
since choline is not a biosynthetic product of prokaryotes, the Pcs pathway is probably a direct sensor of environmental conditions, using choline availability as an indicator of the status of the location in which the bacterium is found |
Fluoribacter dumoffii |
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
2.7.8.24 |
gene pcsA, DNA and amino acid sequence determination and analysis |
Fluoribacter dumoffii |
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
2.7.8.24 |
membrane |
localization of phosphatidylcholine in the outer and inner membranes by LC/ESI-MS analysis |
Fluoribacter dumoffii |
16020 |
- |
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
2.7.8.24 |
CDP-diacylglycerol + choline |
Fluoribacter dumoffii |
the enzyme utilizes exogenous choline for phosphatidylcholine synthesis |
CMP + phosphatidylcholine |
- |
r |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.8.24 |
Fluoribacter dumoffii |
S4X5L9 |
gene pcsA |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.7.8.24 |
CDP-diacylglycerol + choline |
- |
Fluoribacter dumoffii |
CMP + phosphatidylcholine |
- |
r |
|
2.7.8.24 |
CDP-diacylglycerol + choline |
the enzyme utilizes exogenous choline for phosphatidylcholine synthesis |
Fluoribacter dumoffii |
CMP + phosphatidylcholine |
- |
r |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.7.8.24 |
PcsA |
- |
Fluoribacter dumoffii |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.7.8.24 |
metabolism |
the phosphatidylcholine synthase pathway is the primary pathway for synthesis of phosphatidylcholine in Legionelly dumoffii. Choline is condensed directly with CDP-diacylglyceride to form phosphatidylcholine in a reaction catalyzed by a bacterium-specific Pcs enzyme |
Fluoribacter dumoffii |
2.7.8.24 |
physiological function |
the enzyme synthesizes phosphatidylcholine, a membrane-forming phospholipid, via the phosphatidylcholine synthase pathway, Pcs. Structurally different PC species are distributed in the outer and inner membranes |
Fluoribacter dumoffii |