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Literature summary extracted from

  • Ohniwa, R.; Kitabayashi, K.; Morikawa, K.
    Alternative cardiolipin synthase Cls1 compensates for stalled Cls2 function in Staphylococcus aureus under conditions of acute acid stress (2013), FEMS Microbiol. Lett., 338, 141-146.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.B10 additional information enzyme Cls1 can induce CL production in response to broad high osmolality stressors, such as 4 M NaCl, 4 M KCl or 20% raffinose in the cls2 mutant (Ncls2), although not in the wild-type Staphylococcus aureus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.B10 gene cls1, phylogenetic analysis Staphylococcus aureus
2.7.8.B10 gene cls2, cls2 encodes a housekeeping-type CL synthase, phylogenetic analysis Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol Staphylococcus aureus
-
 a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol Staphylococcus aureus N315
-
 a cardiolipin + glycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.B10 Staphylococcus aureus A0A0H3JKV8
-
-
2.7.8.B10 Staphylococcus aureus P63801
-
-
2.7.8.B10 Staphylococcus aureus N315 A0A0H3JKV8
-
-
2.7.8.B10 Staphylococcus aureus N315 P63801
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol
-
 Staphylococcus aureus a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol
-
 Staphylococcus aureus N315 a cardiolipin + glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.B10 cardiolipin synthase
-
 Staphylococcus aureus
2.7.8.B10 CL synthase
-
 Staphylococcus aureus
2.7.8.B10 CLS1
-
 Staphylococcus aureus
2.7.8.B10 cls2
-
 Staphylococcus aureus
2.7.8.B10 SA1155
-
 Staphylococcus aureus
2.7.8.B10 SA1891
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.7.8.B10 evolution phylogenetic analysis reveals that gene cls1 is generated through the duplication of gene cls2 after the divergence of the genus Staphylococcus Staphylococcus aureus
2.7.8.B10 malfunction a cls1 mutant is equal to the wild-type in terms of CL accumulation and stress tolerance. But below pH 2.6, the cls1 mutant (i.e. carrying Cls2 alone) cannot produce cardiolipin Staphylococcus aureus
2.7.8.B10 malfunction a cls2 mutant (carrying Cls1 alone) effectively accumulates cardiolipin at pH 2.6 and below Staphylococcus aureus
2.7.8.B10 physiological function alternative cardiolipin synthase Cls1 compensates for stalled Cls2 function in Staphylococcus aureus under conditions of acute acid stress. Gene cls2 encodes a housekeeping-type CL synthase Staphylococcus aureus
2.7.8.B10 physiological function alternative cardiolipin synthase Cls1 compensates for stalled Cls2 function in Staphylococcus aureus under conditions of acute acid stress. The physiological role of cls1 is to synthesize cardiolipin under conditions of acute low-pH stress Staphylococcus aureus