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Literature summary extracted from

  • Ghosh, S.; Shukla, D.; Suman, K.; Lakshmi, B.J.; Manorama, R.; Kumar, S.; Bhandari, R.
    Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels (2013), Blood, 122, 1478-1486.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.21 gene IP6K1 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.4.21 additional information generation of enzyme-deficient Ip6k1-/- mice, phenotype, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.21 cytoplasm
-
 Mus musculus 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.21 55000
-
 x * 55000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate Mus musculus C57BL/6
-
 ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Mus musculus Q6PD10
-
-
2.7.4.21 Mus musculus Q6PD10 gene IP6K1
-
2.7.4.21 Mus musculus C57BL/6 Q6PD10 gene IP6K1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 blood platelet
-
 Mus musculus
-
2.7.4.21 MEF cell
-
 Mus musculus
-
2.7.4.21 megakaryocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus C57BL/6 ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.21 ? x * 55000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase 1
-
 Mus musculus
2.7.4.21 IP6 kinase 1
-
 Mus musculus
2.7.4.21 IP6K1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.4.21 malfunction significant reduction in platelet polyP levels in enzyme-deficient Ip6k1-/- mice, along with slower platelet aggregation and lengthened plasma clotting time. Incorporation of polyP into fibrin clots is reduced in Ip6k1-/- mice, thereby altering clot ultrastructure, which is rescued on the addition of exogenous polyP. In vivo assays reveal longer tail bleeding time and resistance to thromboembolism in Ip6k1-/- mice. No alteration in P-selectin surface expression in Ip6k1-/- platelets implies that IP6K1 does not influence platelet alpha-granule content or its thrombin-stimulated release No difference in the extent of fibrinogen binding to activated wild-type or Ip6k1-/- platelets, and no difference in serotonin content. Knockout Ip6k1-/- mice show altered clot homogeneity and architecture and a significant increase in the number of fibers per unit length in Ip6k1-/- derived clots compared to wild-type. Hemostasis defects in Ip6k1-/- mice, overview Mus musculus
2.7.4.21 physiological function inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels. Role for IP6K1 in regulation of mammalian hemostasis via its control of platelet polyP levels Mus musculus