Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wundenberg, T.; Grabinski, N.; Lin, H.; Mayr, G.W.
    Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio (2014), Biochem. J., 462, 173-184.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.158 N2-(m-trifluoromethylbenzyl),N6-(p-nitrobenzyl)purine selective inhibitor Homo sapiens
2.7.1.158 N2-(m-trifluoromethylbenzyl),N6-(p-nitrobenzyl)purine selective inhibitor Rattus norvegicus
2.7.4.21 N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine TNP, a selective IP6K inhibitor, abolishes the production of enantiomer Ins(2,3,4,5,6)P5 in different types of cells Homo sapiens
2.7.4.21 N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine TNP, a selective IP6K inhibitor, abolishes the production of enantiomer Ins(2,3,4,5,6)P5 in different types of cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.158 cytosol
-
 Homo sapiens 5829
-
2.7.1.158 cytosol
-
 Rattus norvegicus 5829
-
2.7.1.158 nucleus
-
 Homo sapiens 5634
-
2.7.1.158 nucleus
-
 Rattus norvegicus 5634
-
2.7.4.21 cytosol
-
 Homo sapiens 5829
-
2.7.4.21 cytosol
-
 Rattus norvegicus 5829
-
2.7.4.21 nucleus
-
 Homo sapiens 5634
-
2.7.4.21 nucleus
-
 Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol hexakisphosphate
-
 ?
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate Rattus norvegicus
-
 ADP + 1D-myo-inositol hexakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.158 Homo sapiens
-
-
-
2.7.1.158 Rattus norvegicus
-
-
-
2.7.4.21 Homo sapiens
-
-
-
2.7.4.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.158 blood
-
 Homo sapiens
-
2.7.4.21 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol hexakisphosphate
-
 ?
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol hexakisphosphate
-
 ?
2.7.1.158 additional information the enzyme changes its kinase activity towards 1D-myo-inositol hexakisphosphate at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate 1D-myo-inositol hexakisphosphate Homo sapiens ?
-
 ?
2.7.1.158 additional information the enzyme changes its kinase activity towards 1D-myo-inositol hexakisphosphate at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate 1D-myo-inositol hexakisphosphate Rattus norvegicus ?
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?
2.7.4.21 additional information IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction Homo sapiens ?
-
 ?
2.7.4.21 additional information IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.158 InsP6-kinase
-
 Homo sapiens
2.7.1.158 InsP6-kinase
-
 Rattus norvegicus
2.7.1.158 IP6K
-
 Homo sapiens
2.7.1.158 IP6K
-
 Rattus norvegicus
2.7.4.21 InsP6-kinase
-
 Homo sapiens
2.7.4.21 InsP6-kinase
-
 Rattus norvegicus
2.7.4.21 IP6K
-
 Homo sapiens
2.7.4.21 IP6K
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.4.21 additional information lentiviral RNAi-based depletion of MINPP1 at falling cellular ATP/ADP ratios has no significant impact on Ins(2,3,4,5,6)P5 production Homo sapiens
2.7.4.21 additional information lentiviral RNAi-based depletion of MINPP1 at falling cellular ATP/ADP ratios has no significant impact on Ins(2,3,4,5,6)P5 production Rattus norvegicus
2.7.4.21 physiological function InsP6 (inositol hexakisphosphate), the most abundant inositol phosphate in metazoa, is pyrophosphorylated to InsP7 [5PP-InsP5 (diphosphoinositol pentakisphosphate)] by cytosolic and nuclear IP6Ks (InsP6 kinases) and to 1PP-InsP5 by another InsP6/InsP7 kinase family. IP6Ks are also nuclear and cytosolic InsP6- (and InsP5-)dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio, thus suggesting a role for IP6Ks as cellular adenylate energy sensors Homo sapiens
2.7.4.21 physiological function InsP6 (inositol hexakisphosphate), the most abundant inositol phosphate in metazoa, is pyrophosphorylated to InsP7 [5PP-InsP5 (diphosphoinositol pentakisphosphate)] by cytosolic and nuclear IP6Ks (InsP6 kinases) and to 1PP-InsP5 by another InsP6/InsP7 kinase family. IP6Ks are also nuclear and cytosolic InsP6- (and InsP5-)dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio, thus suggesting a role for IP6Ks as cellular adenylate energy sensors Rattus norvegicus