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Literature summary extracted from

  • Lugo, M.R.; Merrill, A.R.
    The father, son and cholix toxin: The third member of the dt group mono-ADP-ribosyltransferase toxin family (2015), Toxins, 7, 2757-2772.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.36 1H-benzo[de]isoquinoline-1,3(2H)-dione
-
 Pseudomonas aeruginosa
2.4.2.36 2-[(5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-(2-hydroxyethyl)acetamide
-
 Pseudomonas aeruginosa
2.4.2.36 8-fluoro-2-[3-(piperidin-1-yl)propanoyl]-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one
-
 Pseudomonas aeruginosa
2.4.2.36 PJ34
-
 Pseudomonas aeruginosa
2.4.2.36 PJ34
-
 Vibrio cholerae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.36 NAD+ + diphthamide-[translation elongation factor 2] Pseudomonas aeruginosa
-
 nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
 ?
2.4.2.36 NAD+ + diphthamide-[translation elongation factor 2] Vibrio cholerae
-
 nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.36 Pseudomonas aeruginosa P11439
-
-
2.4.2.36 Vibrio cholerae Q5EK40
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.36 NAD+ + diphthamide-[translation elongation factor 2]
-
 Pseudomonas aeruginosa nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
 ?
2.4.2.36 NAD+ + diphthamide-[translation elongation factor 2]
-
 Vibrio cholerae nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.36 cholix toxin
-
 Vibrio cholerae
2.4.2.36 chxA
-
 Vibrio cholerae
2.4.2.36 diphthamide-specific ADPRT
-
 Pseudomonas aeruginosa
2.4.2.36 diphthamide-specific ADPRT
-
 Vibrio cholerae
2.4.2.36 ExoA
-
 Pseudomonas aeruginosa
2.4.2.36 exotoxin A
-
 Pseudomonas aeruginosa