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Literature summary extracted from

  • Chen, H.; He, X.; Geng, H.; Liu, H.
    Physiological characterization of ATP-citrate lyase in Aspergillus niger (2014), J. Ind. Microbiol. Biotechnol., 41, 721-731.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.3.8 expressed in Escherichia coli BL21(DE3) cells Aspergillus niger

Protein Variants

EC Number Protein Variants Comment Organism
2.3.3.8 H305A inactive mutant of isoform Acl1 Aspergillus niger

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.3.8 cytosol
-
 Aspergillus niger 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate Aspergillus niger
-
 ATP + citrate + CoA
-
 ?
2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate Aspergillus niger ATCC 1015
-
 ATP + citrate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.8 Aspergillus niger
-
-
-
2.3.3.8 Aspergillus niger ATCC 1015
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.3.8 Ni-NTA column chromatography Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate
-
 Aspergillus niger ATP + citrate + CoA
-
 ?
2.3.3.8 ADP + phosphate + acetyl-CoA + oxaloacetate
-
 Aspergillus niger ATCC 1015 ATP + citrate + CoA
-
 ?
2.3.3.8 additional information only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein Aspergillus niger ?
-
 ?
2.3.3.8 additional information only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein Aspergillus niger ATCC 1015 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.8 ACL1 isoform Aspergillus niger
2.3.3.8 ACL2 isoform Aspergillus niger
2.3.3.8 ACLY
-
 Aspergillus niger
2.3.3.8 ATP-citrate lyase
-
 Aspergillus niger

General Information

EC Number General Information Comment Organism
2.3.3.8 physiological function isoforms Acl1 and Acl2 coordinately modulate the cytoplasmic acetyl-CoA levels to regulate growth, development, and citric acid synthesis in Aspergillus niger Aspergillus niger