EC Number | Application | Comment | Organism |
---|---|---|---|
2.4.1.345 | medicine | PimA is required for viability during macrophage infection. In two different mouse models of infection a dramatic decrease in viable counts is observed upon silencing of the gene. Depletion of PimA results in complete clearance of the mouse lungs during both the acute and chronic phases of infection | Mycobacterium tuberculosis |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.345 | - |
Mycobacterium tuberculosis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.345 | plasma membrane | - |
Mycobacterium tuberculosis | 5886 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.345 | Mycobacterium tuberculosis | P9WMZ5 | - |
- |
2.4.1.345 | Mycobacterium tuberculosis H37Rv | P9WMZ5 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.345 | phosphatidyl-myo-inositol mannosyltransferase | - |
Mycobacterium tuberculosis |
2.4.1.345 | PimA | - |
Mycobacterium tuberculosis |
2.4.1.345 | Rv2610c | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.57 | malfunction | enzyme depletion is bactericidal | Mycobacterium tuberculosis |
2.4.1.57 | metabolism | the enzyme initiates the biosynthesis of phosphatidyl-myoinositol mannosides by transferring a mannosyl residue from GDP-mannose to phosphatidyl-myo-inositol on the cytoplasmic side of the plasma membrane | Mycobacterium tuberculosis |
2.4.1.57 | physiological function | the enzyme is essential for Mycobacterium tuberculosis growth in vitro and in vivo. The enzyme is essential for growth during the acute and chronic phases of macrophage infection | Mycobacterium tuberculosis |
2.4.1.345 | physiological function | downregulation of PimA expression causes bactericidality in batch cultures associated with markedly reduced levels of phosphatidyl-myo-inositol dimannosides. PimA is required for viability during macrophage infection. In two different mouse models of infection a dramatic decrease in viable counts is observed upon silencing of the gene. Depletion of PimA results in complete clearance of the mouse lungs during both the acute and chronic phases of infection | Mycobacterium tuberculosis |