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Literature summary extracted from

  • Wang, C.; Yang, X.; Wang, E.; Li, B.
    Quantum chemistry studies of adenosine 2503 methylation by S-adenosylmethionine-dependent enzymes (2013), Int. J. Quantum Chem., 113, 1409-1415.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.192 additional information
-
 additional information energy profile and thermodynamics, overview Staphylococcus aureus
2.1.1.224 additional information
-
 additional information energy profile and thermodynamics, overview Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.192 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin Staphylococcus aureus
-
 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
 ?
2.1.1.192 additional information Staphylococcus aureus methylation at C2 is similar to that at C8, cf. EC 2.1.1.224 ?
-
 ?
2.1.1.224 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin Staphylococcus aureus
-
 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
 ?
2.1.1.224 additional information Staphylococcus aureus methylation at C8 is similar to that at C2, cf. EC 2.1.1.192 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.192 Staphylococcus aureus
-
-
-
2.1.1.224 Staphylococcus aureus A5HBL2
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.192 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin reaction mechanism modeling, overview Staphylococcus aureus
a
2.1.1.224 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin reaction mechanism modeling overview Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.192 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
-
 Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
 ?
2.1.1.192 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
 ?
2.1.1.192 additional information methylation at C2 is similar to that at C8, cf. EC 2.1.1.224 Staphylococcus aureus ?
-
 ?
2.1.1.224 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
-
 Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
 ?
2.1.1.224 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
 ?
2.1.1.224 additional information methylation at C8 is similar to that at C2, cf. EC 2.1.1.192 Staphylococcus aureus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.192 RlmN
-
 Staphylococcus aureus
2.1.1.224 Cfr
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.192 Ferredoxin
-
 Staphylococcus aureus
2.1.1.192 S-adenosyl-L-methionine dependent on Staphylococcus aureus
2.1.1.224 Ferredoxin
-
 Staphylococcus aureus
2.1.1.224 S-adenosyl-L-methionine dependent on Staphylococcus aureus