Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Javaid, S.; Saad, S.M.; Perveen, S.; Khan, K.M.; Choudhary, M.I.
    2-Arylquinazolin-4(3H)-ones: A novel class of thymidine phosphorylase inhibitors (2015), Bioorg. Chem., 63, 142-151.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 2-(2',5'-dihydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2.4.2.4 2-(3',4'-dihydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2.4.2.4 2-(3'-ethoxy-4'-hydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2.4.2.4 2-(3'-hydroxy-4'-methoxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2.4.2.4 2-(3'-hydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2.4.2.4 2-(4'-hydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2.4.2.4 7-deazaxanthine non-competitive inhibition Escherichia coli
2.4.2.4 cycloheximide
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 thymidine + phosphate Escherichia coli
-
 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 dthdpase
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.4 0.0002
-
 at pH 7.0 and 30°C Escherichia coli cycloheximide
2.4.2.4 0.041
-
 at pH 7.0 and 30°C Escherichia coli 7-deazaxanthine
2.4.2.4 0.0429
-
 at pH 7.0 and 30°C Escherichia coli 2-(3',4'-dihydroxyphenyl)quinazolin-4(3H)-one
2.4.2.4 0.0595
-
 at pH 7.0 and 30°C Escherichia coli 2-(2',5'-dihydroxyphenyl)quinazolin-4(3H)-one
2.4.2.4 0.1688
-
 at pH 7.0 and 30°C Escherichia coli 2-(3'-hydroxy-4'-methoxyphenyl)quinazolin-4(3H)-one
2.4.2.4 0.234
-
 at pH 7.0 and 30°C Escherichia coli 2-(4'-hydroxyphenyl)quinazolin-4(3H)-one
2.4.2.4 0.256
-
 at pH 7.0 and 30°C Escherichia coli 2-(3'-ethoxy-4'-hydroxyphenyl)quinazolin-4(3H)-one
2.4.2.4 0.295
-
 at pH 7.0 and 30°C Escherichia coli 2-(3'-hydroxyphenyl)quinazolin-4(3H)-one