Literature summary extracted from

Dulermo, T.; Lazar, Z.; Dulermo, R.; Rakicka, M.; Haddouche, R.; Nicaud, J.M.
Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis (2015), Biochim. Biophys. Acta, 1851, 1107-1117.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.3.3.8	cytosol	-	Yarrowia lipolytica	5829	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.3.8	ADP + phosphate + acetyl-CoA + oxaloacetate	Yarrowia lipolytica	-	ATP + citrate + CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.82	no activity in Yarrowia lipolytica	-	-	-
2.3.3.8	Yarrowia lipolytica	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.3.8	ADP + phosphate + acetyl-CoA + oxaloacetate	-	Yarrowia lipolytica	ATP + citrate + CoA	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.3.8	ACL	-	Yarrowia lipolytica
2.3.3.8	ATP-citrate lyase	-	Yarrowia lipolytica

General Information

EC Number	General Information	Comment	Organism
2.3.3.8	malfunction	enzyme inactivation decreases fatty acid synthesis by 60 to 80%	Yarrowia lipolytica
2.3.3.8	metabolism	the enzyme plays an essential role in fatty acid synthesis	Yarrowia lipolytica

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Release 2023.1 (January 2023)