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Literature summary extracted from

  • Mavromatakis, Y.E.; Tomlinson, A.
    The role of the small GTPase Rap in Drosophila R7 photoreceptor specification (2012), Proc. Natl. Acad. Sci. USA, 109, 3844-3849.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.2 GTP + H2O Drosophila melanogaster
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.2 Drosophila melanogaster P08645
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.2 eye the enzyme is expressed in the R7 photoreceptor, localization study, overview Drosophila melanogaster
-
3.6.5.2 photoreceptor cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.2 GTP + H2O
-
 Drosophila melanogaster GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.2 RAP
-
 Drosophila melanogaster
3.6.5.2 small GTPase
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.6.5.2 evolution the enzyme belongs to the Ras superfamily Drosophila melanogaster
3.6.5.2 metabolism photoreceptor R7 is specified by the combined actions of the receptor tyrosine kinase (RTK) and Notch (N) signaling pathways. These pathways interact in a complex manner that includes antagonistic effects on photoreceptor specification and involve the small GTPase Rap. RTK promotes the photoreceptor fate, whereas N inhibits it Drosophila melanogaster
3.6.5.2 physiological function requirement for rap gene function in photoreceptor R7, localization of rap gene activity, overview. Overactivity of Ras GTPase activating proteins or underactivity of Ras guanine exchange factors, among other possibilities might account for the limitation in the Ras pathway Drosophila melanogaster