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Literature summary extracted from

  • Yu, Y.; Liu, X.; Wang, H.; Li, X.; Lin, J.
    Construction and characterization of tetH overexpression and knockout strains of Acidithiobacillus ferrooxidans (2014), J. Bacteriol., 196, 2255-2264.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.12.1.B1 gene tetH, genes tetH and doxD2 act synergistically, and doxD2 is considered important in thiosulfate metabolism, quantitative reverse transcription-PCR analysis Acidithiobacillus ferrooxidans

Protein Variants

EC Number Protein Variants Comment Organism
3.12.1.B1 additional information construction of a tetH knockout mutant DELTAtetH and a tetH overexpression strain, the tetH overexpression strain grows better on sulfur and tetrathionate and possesses a higher rate of tetrathionate utilization and TetH activity than the wild-type. The DELTAtetH mutant cannot grow on tetrathionate but can proliferate on sulfur with a lower cell yield than the wild type Acidithiobacillus ferrooxidans

Organism

EC Number Organism UniProt Comment Textmining
3.12.1.B1 Acidithiobacillus ferrooxidans B7J3C9 gene tetH
-

Synonyms

EC Number Synonyms Comment Organism
3.12.1.B1 Teth
-
 Acidithiobacillus ferrooxidans

General Information

EC Number General Information Comment Organism
3.12.1.B1 malfunction the DELTAtetH mutant can survive in ferrous medium with an Fe2+ oxidation rate similar to that of the wild-type. For the tetH overexpression strain, the rate is relatively higher than that of the wild type Acidithiobacillus ferrooxidans
3.12.1.B1 metabolism the organism can obtain energy from the oxidation of Fe2+, H2, and sulfur, and various reduced inorganic sulfur compounds (RISCs). Tetrathionate is a key intermediate during RISC oxidation, hydrolyzed by tetrathionate hydrolase (TetH), and used as sole energy source. Genes tetH and doxD2 act synergistically, and doxD2 is considered important in thiosulfate metabolism Acidithiobacillus ferrooxidans
3.12.1.B1 physiological function the enzyme is a key enzyme in hydrolysis of tetrathionate for usage as sole energy source Acidithiobacillus ferrooxidans