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Literature summary extracted from

  • Nishino, H.; Nishi, S.; Ishibashi, T.
    Nine of ten histidine residues, located in three conserved clusters, are required for mammalian sterol C5-desaturase activity (2003), Biomed. Res., 24, 99-106.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.20 expressed in a Saccharomyces cerevisiae erg3-deficient mutant strain Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.20 cyanide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.20 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.14.19.20 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.19.20 Iron required Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.20 30000
-
 x * 30000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.20 Homo sapiens O75845
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.20 ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens ergosta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.20 ? x * 30000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.19.20 ERG3
-
 Homo sapiens
1.14.19.20 SCSD
-
 Homo sapiens
1.14.19.20 sterol C5-desaturase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.20 cytochrome b5
-
 Homo sapiens
1.14.19.20 NADH
-
 Homo sapiens