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Literature summary extracted from

  • Sayasith, K.; Sirois, J.; Lussier, J.G.
    Expression, regulation, and promoter activation of vanin-2 (VNN2) in bovine follicles prior to ovulation (2013), Biol. Reprod., 89, 98.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.92 gene VNN2, semiquantitative RT-PCR expression analysis in ovulatory follicles and granulosa cells, DNA-binding activity of bovine VNN2 promoter, overview Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.92 additional information construction of several VNN2 promoter-deletion mutants: deletion of the region between -1107 and -530 result in a marked and significant increase of basal and forskolin-stimulated promoter activities, suggesting factors repressing the promoter activity in this region. This region contains a number of consensus cis-acting elements of which COUP-TF, GATA, and Ebox appears to play a key role, as revealed by site-directed mutagenesis and promoter activity assays. Deletion between -530 and -262 markedly decreased basal and forskolin-stimulated promoter activities as compared to the-530VNN2.LUC construct. Further deletions do not change promoter activities, thus identifying the region -530/-262 as important in the regulation of the VNN2 promoter activity in bovine granulosa cells Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.92 Bos taurus A5D9D1
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-
3.5.1.92 Bos taurus Holstein A5D9D1
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.92 granulosa cell regulation of VNN2 transcripts in bovine follicles prior to ovulation, high levels of gonadotropins regulate VNN2 mRNA expression in granulosa cells of bovine preovulatory follicles Bos taurus
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3.5.1.92 ovarian follicle ovulatory, regulation of VNN2 transcripts in bovine follicles prior to ovulation, high expression level during the ovulatory process Bos taurus
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Synonyms

EC Number Synonyms Comment Organism
3.5.1.92 vanin-2
-
 Bos taurus
3.5.1.92 VNN2
-
 Bos taurus

Expression

EC Number Organism Comment Expression
3.5.1.92 Bos taurus VNN2 promoter activity and mRNA expression are inhibited by protein kinase A and ERK1/2 inhibitors down
3.5.1.92 Bos taurus VNN2 promoter activity and mRNA expression are markedly stimulated by forskolin and overexpression of the catalytic subunit of protein kinase A up

General Information

EC Number General Information Comment Organism
3.5.1.92 physiological function vanin-2 is known to be involved in inflammation and leukocyte migration Bos taurus