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Literature summary extracted from

  • Marzo, I.; Alava, M.A.; Pineiro, A.; Naval, J.
    Biosynthesis of docosahexaenoic acid in human cells: Evidence that two different DELTA 6-desaturase activities may exist (1996), Biochim. Biophys. Acta, 1301, 263-272.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.47 trans-9,12-linoleic acid potent inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.47 alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
1.14.19.47 linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.47 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.47 JURKAT cell
-
 Homo sapiens
-
1.14.19.47 retinoblastoma cell
-
 Homo sapiens
-
1.14.19.47 Y-79 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.47 alpha-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens stearidonoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
1.14.19.47 linoleoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.47 DELTA 6-desaturase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.47 cytochrome b5
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.19.47 Homo sapiens neuronal differentiation of Y-79 cells causes a great increase in enzyme activity up