Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Beceiro, A.; Llobet, E.; Aranda, J.; Bengoechea, J.A.; Doumith, M.; Hornsey, M.; Dhanji, H.; Chart, H.; Bou, G.; Livermore, D.M.; Woodford, N.
    Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system (2011), Antimicrob. Agents Chemother., 55, 3370-3379.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.43 gene pmrA, genetic organization of the pmrCAB genes, PCR-based expression analysis in colistin sensitive and resistant strains Acinetobacter baumannii

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.43 Acinetobacter baumannii E2FGC2 diverse colistin sensitive and resistant strains, gene pmrA
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.43 additional information colistin resistant strains show higher enzyme expression compared to colistin sensitive strains, enzyme expression analysis, overview Acinetobacter baumannii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.43 additional information addition of phosphoethanolamine to hepta-acylated lipid A Acinetobacter baumannii ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.43 PmrA
-
 Acinetobacter baumannii

Expression

EC Number Organism Comment Expression
2.7.8.43 Acinetobacter baumannii no upregulation of pmrA by Fe3+ and Mg2+ in strain ATCC 19606 additional information

General Information

EC Number General Information Comment Organism
2.7.8.43 malfunction point mutations in the PmrA/B two-component system lead to colistin resistance Acinetobacter baumannii
2.7.8.43 metabolism the development of a moderate level of colistin resistance in Acinetobacter baumannii requires distinct genetic events, including (i) at least one point mutation in pmrB, (ii) upregulation of pmrAB, and (iii) expression of pmrC, which lead to addition of phosphoethanolamine to lipid A Acinetobacter baumannii
2.7.8.43 physiological function phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii, e.g. strain ATCC 19606, is mediated by the pmrAB two-component regulatory system Acinetobacter baumannii