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Literature summary extracted from

  • Laarman, A.J.; Mijnheer, G.; Mootz, J.M.; van Rooijen, W.J.; Ruyken, M.; Malone, C.L.; Heezius, E.C.; Ward, R.; Milligan, G.; van Strijp, J.A.; de Haas, C.J.; Horswill, A.R.; van Kessel, K.P.; Rooijakkers, S.H.
    Staphylococcus aureus staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis (2012), EMBO J., 31, 3607-3619.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.48 E-64
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.48 CXCR2 + H2O Staphylococcus aureus the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36 ?
-
 ?
3.4.22.48 CXCR2 + H2O Staphylococcus aureus MRSA the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36 ?
-
 ?
3.4.22.48 additional information Staphylococcus aureus staphopain A does not cleave human CXCR1 ?
-
 ?
3.4.22.48 additional information Staphylococcus aureus MRSA staphopain A does not cleave human CXCR1 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.48 Staphylococcus aureus
-
-
-
3.4.22.48 Staphylococcus aureus MRSA
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.48 CXCR2 + H2O the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36 Staphylococcus aureus ?
-
 ?
3.4.22.48 CXCR2 + H2O the enzyme specifically cleaves the N-terminal domain of human CXCR2 between asparate-35 and alanine-36 Staphylococcus aureus MRSA ?
-
 ?
3.4.22.48 additional information staphopain A does not cleave human CXCR1 Staphylococcus aureus ?
-
 ?
3.4.22.48 additional information staphopain A does not cleave human CXCR1 Staphylococcus aureus MRSA ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.48 staphylopain
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.4.22.48 physiological function staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis Staphylococcus aureus