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Literature summary extracted from

  • Majumder, P.; Aranjuez, G.; Amick, J.; McDonald, J.A.
    Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration (2012), Curr. Biol., 22, 363-372.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.53 Drosophila melanogaster
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-
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.53 phosphoprotein Par-1 (cell polarity protein) activates Myo-II by phosphorylating and inhibiting the myosin phosphatase complex Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
3.1.3.53 MYL phosphatase
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 Drosophila melanogaster
3.1.3.53 MYLP
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.1.3.53 physiological function Par-1 (cell polarity protein) binds to myosin phosphatase and phosphorylates it at a known inactivating site. Par-1 thus promotes phosphorylated myosin regulatory light chain, thereby increasing Myo-II activity Drosophila melanogaster