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Literature summary extracted from

  • Khan, I.; Suhasini, A.N.; Banerjee, T.; Sommers, J.A.; Kaplan, D.L.; Kuper, J.; Kisker, C.; Brosh, R.M.
    Impact of age-associated cyclopurine lesions on DNA repair helicases (2014), PLoS One, 9, e113293.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.3 (5'R)-8,5'-cyclo-2'-deoxyguanosine the enzyme is strongly inhibited by (5'R)-8,5'-cyclo-2'-deoxyguanosine in the non-translocating strand Thermoplasma acidophilum
5.6.2.3 (5'S)-8,5'-cyclo-2'-deoxyguanosine the enzyme is strongly inhibited by (5'S)-8,5'-cyclo-2'-deoxyguanosine in the non-translocating strand. At 40 nM enzyme, less than 10% of the forked duplex with (5'S)-8,5'-cyclo-2'-deoxyguanosine in the nontranslocating strand is unwound compared to 60% of the control forked duplex or the substrate with (5'S)-8,5'-cyclo-2'-deoxyguanosine in the translocating strand Thermoplasma acidophilum

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.3 Thermoplasma acidophilum Q9HM14
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.3 ATP + H2O utilizes the energy from ATP hydrolysis to unwind DNA with 5' to 3' polarity Thermoplasma acidophilum ADP + phosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.3 XDP
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 Thermoplasma acidophilum