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Literature summary extracted from

  • Lin, Z.; Su, X.; Chen, W.; Ci, B.; Zhang, S.; Lin, H.
    Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis (2014), J. Am. Chem. Soc., 136, 6179-6182.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.98 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidine-[translation elongation factor 2] Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidine-[translation elongation factor 2]
-
 ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] Saccharomyces cerevisiae the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] Saccharomyces cerevisiae ATCC 204508 the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O Saccharomyces cerevisiae
-
 diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O Saccharomyces cerevisiae the enzyme is involved in diphthamide biosynthesis pathway diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O Homo sapiens the enzyme is involved in diphthamide biosynthesis pathway diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O Saccharomyces cerevisiae ATCC 204508
-
 diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O Saccharomyces cerevisiae ATCC 204508 the enzyme is involved in diphthamide biosynthesis pathway diphthine-[translation elongation factor 2] + methanol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.98 Saccharomyces cerevisiae
-
-
-
2.1.1.314 Saccharomyces cerevisiae P32469
-
-
2.1.1.314 Saccharomyces cerevisiae ATCC 204508 P32469
-
-
3.1.1.97 Homo sapiens Q9BTV6
-
-
3.1.1.97 Saccharomyces cerevisiae P38332
-
-
3.1.1.97 Saccharomyces cerevisiae ATCC 204508 P38332
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.98 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidine-[translation elongation factor 2]
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidine-[translation elongation factor 2]
-
 ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the relevant histidine of elongation factor 2 is His699 in Saccharomyces cerevisiae Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity Saccharomyces cerevisiae ATCC 204508 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
2.1.1.314 4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the relevant histidine of elongation factor 2 is His699 in Saccharomyces cerevisiae Saccharomyces cerevisiae ATCC 204508 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O
-
 Saccharomyces cerevisiae diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O the enzyme is involved in diphthamide biosynthesis pathway Saccharomyces cerevisiae diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O the enzyme is involved in diphthamide biosynthesis pathway Homo sapiens diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine Saccharomyces cerevisiae diphthine-[translation elongation factor 2] + methanol diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine Homo sapiens diphthine-[translation elongation factor 2] + methanol diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O
-
 Saccharomyces cerevisiae ATCC 204508 diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O the enzyme is involved in diphthamide biosynthesis pathway Saccharomyces cerevisiae ATCC 204508 diphthine-[translation elongation factor 2] + methanol
-
 ?
3.1.1.97 diphthine methyl ester-[translation elongation factor 2] + H2O diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine Saccharomyces cerevisiae ATCC 204508 diphthine-[translation elongation factor 2] + methanol diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.98 Dph5
-
 Saccharomyces cerevisiae
2.1.1.314 Dph5
-
 Saccharomyces cerevisiae
3.1.1.97 Dph7
-
 Saccharomyces cerevisiae
3.1.1.97 Dph7
-
 Homo sapiens
3.1.1.97 WDR85 locus name Homo sapiens
3.1.1.97 YBR246W locus name Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.1.1.314 metabolism the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide Saccharomyces cerevisiae
3.1.1.97 metabolism the enzyme is involved in diphthamide biosynthesis pathway Saccharomyces cerevisiae
3.1.1.97 metabolism the enzyme is involved in diphthamide biosynthesis pathway Homo sapiens
3.1.1.97 metabolism the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide Saccharomyces cerevisiae