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Literature summary extracted from

  • Haimovich, A.; Eliav, U.; Goldbourt, A.
    Determination of the lithium binding site in inositol monophosphatase, the putative target for lithium therapy, by magic-angle-spinning solid-state NMR (2012), J. Am. Chem. Soc., 134, 5647-5651.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.25 expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.25 Li+ strongly inhibited by Li+ (complete inhibition at 2 mM) Escherichia coli
3.1.3.25 Mg2+ activity is significantly reduced at high concentrations of Mg2+ Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.25 Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.25 myo-inositol phosphate + H2O Escherichia coli
-
 myo-inositol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.25 Q sepharose column chromatography Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 myo-inositol phosphate + H2O
-
 Escherichia coli myo-inositol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.25 IMPase
-
 Escherichia coli
3.1.3.25 inositol monophosphatase
-
 Escherichia coli
3.1.3.25 SuhB
-
 Escherichia coli