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Literature summary extracted from
- Cardiolipin synthase is required for Streptomyces coelicolor morphogenesis (2012), Mol. Microbiol., 84, 181-197.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.41 | a CDP-diacylglycerol + a phosphatidylglycerol | Streptomyces coelicolor | cardiolipin synthesis is a requirement for morphogenesis in Streptomyces | a cardiolipin + CMP | - |
? |  |
| 2.7.8.41 | a CDP-diacylglycerol + a phosphatidylglycerol | Streptomyces coelicolor A3(2) | cardiolipin synthesis is a requirement for morphogenesis in Streptomyces | a cardiolipin + CMP | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.8.41 | Streptomyces coelicolor | Q9KZP3 | - |
- |
| 2.7.8.41 | Streptomyces coelicolor A3(2) | Q9KZP3 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.41 | a CDP-diacylglycerol + a phosphatidylglycerol | - |
Streptomyces coelicolor | a cardiolipin + CMP | - |
? | |
| 2.7.8.41 | a CDP-diacylglycerol + a phosphatidylglycerol | cardiolipin synthesis is a requirement for morphogenesis in Streptomyces | Streptomyces coelicolor | a cardiolipin + CMP | - |
? | |
| 2.7.8.41 | a CDP-diacylglycerol + a phosphatidylglycerol | - |
Streptomyces coelicolor A3(2) | a cardiolipin + CMP | - |
? | |
| 2.7.8.41 | a CDP-diacylglycerol + a phosphatidylglycerol | cardiolipin synthesis is a requirement for morphogenesis in Streptomyces | Streptomyces coelicolor A3(2) | a cardiolipin + CMP | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.8.41 | clsA | - |
Streptomyces coelicolor |
| 2.7.8.41 | Sco1389 | - |
Streptomyces coelicolor |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.7.8.41 | malfunction | overexpression of clsA results in weakened hyphal tips, misshaped aerial hyphae and anucleate spores and demonstrates that cardiolipin synthesis is a requirement for morphogenesis in Streptomyces | Streptomyces coelicolor |
| 2.7.8.41 | physiological function | cardiolipin synthesis is a requirement for morphogenesis in Streptomyces | Streptomyces coelicolor |
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Release 2023.1 (January 2023)
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