Literature summary extracted from

Mitchell, T.; Ketley, J.; Burdon, D.; Candy, D.; Stephen, J.
The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro (1987), J. Med. Microbiol., 23, 205-210.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.B62	Clostridioides difficile	-	-	-

General Information

EC Number	General Information	Comment	Organism
2.4.1.B62	physiological function	toxin A, toxin B or crude toxin preparations have no effect on membrane integrity of either intestinal cells or McCoy cells as judged by nucleotide leakage. Toxins A and B, on their own ortogether in crude preparations, have no effect on the rate of protein synthesis in isolated intestinal cells in vitro. Both toxins inhibit protein synthesis in McCoy cells, and inhibition of protein synthesis could be a causative factor in the development of cytopathic effects	Clostridioides difficile

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Release 2023.1 (January 2023)