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Literature summary extracted from

  • Liu, J.; Zhu, J.; Tang, L.; Wen, W.; Lv, S.; Yu, R.
    Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation (2013), World J. Microbiol. Biotechnol., 30, 175-180.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.20 gene D4H, semi-quantitative RT-PCR expression analysis Catharanthus roseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.20 deacetoxyvindoline + 2-oxoglutarate + O2 Catharanthus roseus
-
 deacetylvindoline + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.20 Catharanthus roseus
-
 gene D4H
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.20 cell suspension culture
-
 Catharanthus roseus
-
1.14.11.20 leaf
-
 Catharanthus roseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.20 deacetoxyvindoline + 2-oxoglutarate + O2
-
 Catharanthus roseus deacetylvindoline + succinate + CO2
-
 ?

Expression

EC Number Organism Comment Expression
1.14.11.20 Catharanthus roseus artemisinic acid leads to upregulation of the deacetoxyvindoline 4-hydroxylase and upstream enzymes of the vinblastine biosynthesis, i.e. tryptophan decarboxylase, geraniol 10-hydroxylase, tabersonine 16-hydroxylase up