EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.188 | gene PGFS, DNA and amino acid sequence determination and analysis | Felis catus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.188 | prostaglandin H2 + NADP+ | Felis catus | - |
prostaglandin F2alpha + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.188 | Felis catus | E2IGW3 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.188 | uterine endometrium | at oestrus and mid and late phases of pseudopregnancy | Felis catus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.188 | prostaglandin H2 + NADP+ | - |
Felis catus | prostaglandin F2alpha + NADPH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.188 | 9,11-endoperoxidase reductase | - |
Felis catus |
1.1.1.188 | PGF2alpha synthase | - |
Felis catus |
1.1.1.188 | PGFS | - |
Felis catus |
1.1.1.188 | prostaglandin F2alpha synthase | - |
Felis catus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.188 | NADP+ | - |
Felis catus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.1.1.188 | Felis catus | treatment with estradiol and/or progesterone affects neither PGF2alpha secretion nor enzyme PGFS expression at any phase after 12 h of culture, while related enzymes PG-endoperoxide synthase (PTGS2) and PGE2 synthase (PGES) are both upregulated by estradiol and progesterone during pseudopregnancy | additional information |
1.1.1.188 | Felis catus | expression is significantly up-regulated by oestradiol plus progesterone at oestrus and the mid phase of pseudopregnancy and is also up-regulated by a single treatment with progesterone at late pseudopregnancy. Simultaneous incubation with oestradiol and progesterone up-regulates prostaglandin-endoperoxide synthase PTGS2 gene expression at oestrus and mid-luteal phase. Treatment with oestradiol and /or progesterone affects neither prostaglandin F2alpha secretion nor prostaglandin F2alpha synthase expression at any phase after 12 h of culture | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.188 | metabolism | the prostaglandin H2 (PGH2) is the common precursor of prostaglandin F2alpha (PGF2alphha) and prostaglandin E2 (PGE2). PGH2 is converted into one of the active prostaglandins by a specific terminal synthase, such as PGE2 synthase (PGES), which is responsible for PGE2 production or 9,11-endoperoxidase reductase, which has PGF2alpha synthase (PGFS) activity | Felis catus |