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Literature summary extracted from

  • Priyadarshi, A.; Kim, E.; Hwang, K.
    Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP end triclosan (2010), Proteins Struct. Funct. Bioinform., 78, 480-486.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.39 apo-enzyme and complex with NADPH and inhibitor triclosan. Enzyme is a tetramer. In the apo-form of the SaFabI structure, residues Ile193 to Leu196 form part of a flexible loop adjacent to the active site. In the open conformation, the loop is on the surface of the protein, and does not form any secondary structure or contribute to inhibitor or cofactor binding. The substrate-binding loop of the holo-enzyme containing Ser197, Val201 and Phe204 has a closed conformation Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.39 triclosan affinity varies with pH-value Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.39 Staphylococcus aureus Q6GI75
-
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.39 FabI
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.39 NADPH
-
 Staphylococcus aureus